BBC - GCSE Bitesize: Human trials. It is important that the results of clinical trials are not influenced by the expectations of the people involved. So volunteers are put into two groups at random. Checks are done to make sure both groups have a similar gender balance and age range. In blind and double- blind trials one group of volunteers, called the test group, receives the new drug. Another, the control group, receives the existing drug for that illness. If there is no existing treatment, the control group is given a fake drug that has no effect on the body. This is called a placebo. The researchers look for differences between the experimental group and the control group. In an open- label trial there are some differences. Limitations of the Double-Blind Pharmaceutical Study: Vernon M Neppe MD, PhD, FRSSAf, DFAPA, BN&NP, MMed, DPsM, FRCPC, FFPsycha. Advantages and Disadvantages of Various Randomized Clinical Trial Designs Brian Leroux [email protected] University of Washington IADR/AADR Satellite Symposium: Updates in Clinical Research Methodology March 18, 2013 Supported by NIDCR grants1. Advantages and disadvantages of double blind trials? Blind trials. In a blind trial, the volunteers do not know which group they are in but the researchers do. The problem is the researchers may give away clues to the volunteers without realising it. This is called observer bias; it can make the results unreliable. Double- blind trials. In a double- blind trial, the volunteers do not know which group they are in, and neither do the researchers, until the end of the trial. This removes the chance of bias and makes the results more reliable. But double- blind trials are more complex to set up. Open- label trials. In an open- label trial the patient and doctor both know the treatment. This type of trial happens when there is no other treatment and the patients are so ill that doctors believe they will not recover from their illnesses. Placebos. Many doctors do not like giving a placebo to patients with a disease because they feel the patient will not benefit from taking a fake drug and will not get better. They do not think this is fair to the patient. Now try a Test Bite - higher tier. ![]() ![]() ![]()
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